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Anticorps Polyclonal de lapin anti-RHNO1

RHNO1 Polyclonal Antibody for IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

Conjugaison

Non conjugué

N° de cat : 27977-1-PBS

Synonymes

C12orf32, HKMT1188, HUS1, RAD1, RAD9

Galerie de données de validation

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  • Immunoprecipitation (IP) experiment of mouse thymus tissue using RHNO1 Polyclonal antibody (27977-1-AP)

    IP experiment of mouse thymus using 27977-1-AP (same clone as 27977-1-PBS)

    IP result of anti-RHNO1 (IP:27977-1-AP, 4ug; Detection:27977-1-AP 1:500) with mouse thymus tissue lysate 1320 ug. This data was developed using the same antibody clone with 27977-1-PBS in a different storage buffer formulation.

Informations sur le produit

27977-1-PBS cible RHNO1 dans les applications de et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène RHNO1 Protéine recombinante Ag14789
Nom complet chromosome 12 open reading frame 32
Masse moléculaire calculée 238 aa, 27 kDa
Poids moléculaire observé35 kDa
Numéro d’acquisition GenBankBC005106
Symbole du gène C12orf32
Identification du gène (NCBI) 83695
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RHNO1 (Rad9-Hus1-Rad1 Interacting Nuclear Orphan 1) is a protein associated with the DNA replication stress (DRS) response and DNA repair. It interacts with the 9-1-1 checkpoint clamp and TopBP1 to activate the ATR/Chk1 signaling pathway, thereby maintaining genomic integrity. Additionally, RHNO1 has been identified as a key facilitator of theta-mediated end joining (TMEJ), a DNA repair mechanism related to cancer progression and chemotherapy resistance. In cancer research, RHNO1 is considered a potential therapeutic target due to its high expression in tumor cells and its regulatory role in cell proliferation and survival.

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