Anticorps Monoclonal anti-RNASEH2A

RNASEH2A Monoclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Mouse / IgG2a

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1A2E8

N° de cat : 67976-1-PBS

Synonymes

AGS4, Aicardi-Goutieres syndrome 4 protein, EC:3.1.26.4, JUNB, Ribonuclease H2 subunit A

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Galerie de données de validation

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  WB analysis using 67976-1-Ig (same clone as 67976-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67976-1-Ig (RNASEH2A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67976-1-PBS in a different storage buffer formulation.

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  IHC staining of human skin cancer using 67976-1-Ig (same clone as 67976-1-PBS)

  Immunohistochemical analysis of paraffin-embedded skin cancer slide using 67976-1-Ig (RNASEH2A antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67976-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67976-1-PBS cible RNASEH2A dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG2a
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: RNASEH2A Protéine recombinante Ag9256
• Nom complet: ribonuclease H2, subunit A
• Masse moléculaire calculée: 299 aa, 33 kDa
• Poids moléculaire observé: 33 kDa
• Numéro d’acquisition GenBank: BC011748
• Symbole du gène: RNASEH2A
• Identification du gène (NCBI): 10535
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RNASEH2A(Ribonuclease H2 subunit A) is also named as RNASEHI, RNHIA and belongs to the RNase HII family and Eukaryotic subfamily. It is involved in the removal of the initiator RNA primers of Okazaki fragments, an essential step during chromosomal DNA replication of the lagging strand(PMID:9482870). It is an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Defects in RNASEH2A are the cause of Aicardi-Goutieres syndrome type 4 (AGS4).

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