Anticorps Polyclonal de lapin anti-RNF183

RNF183 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32715-1-PBS

Synonymes

E3 ubiquitin-protein ligase RNF183, EC:2.3.2.27

---

Galerie de données de validation

• 

  WB analysis using 32715-1-AP (same clone as 32715-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 32715-1-AP (RNF183 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32715-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

32715-1-PBS cible RNF183 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: RNF183 Protéine recombinante Ag36228
• Nom complet: ring finger protein 183
• Poids moléculaire observé: 30 kDa
• Numéro d’acquisition GenBank: BC013036
• Symbole du gène: RNF183
• Identification du gène (NCBI): 138065
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RNF183, or Ring Finger Protein 183, is a member of the RING finger protein family that functions as a ubiquitin ligase. RNF183 exhibits tissue-specific expression patterns, with higher expression levels in the gall bladder, kidney, and other tissues. RNF183 expression levels are increased in patients with IBD, including Crohn's disease and ulcerative colitis (PMID: 32486221). It promotes intestinal inflammation by increasing the ubiquitination and degradation of IkappaBalpha, thereby inducing NF-kappaB activation (PMID: 31889078). RNF183 has also been implicated in other conditions such as chronic kidney disease and Alzheimer's disease.

{{ptg:RelatedPrimaryAntibodies}}