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Anticorps Polyclonal de lapin anti-RPRD2

RPRD2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33037-1-PBS

Synonymes

HSPC099, KIAA0460, Regulation of nuclear pre-mRNA domain-containing protein 2

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using RPRD2 Polyclonal antibody (33037-1-AP)

    WB analysis using 33037-1-AP (same clone as 33037-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33037-1-AP (RPRD2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33037-1-PBS in a different storage buffer formulation.

Informations sur le produit

33037-1-PBS cible RPRD2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène RPRD2 Protéine recombinante Ag35410
Nom complet regulation of nuclear pre-mRNA domain containing 2
Masse moléculaire calculée155 kDa
Poids moléculaire observé220 kDa
Numéro d’acquisition GenBankBC045623
Symbole du gène RPRD2
Identification du gène (NCBI) 23248
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

RPRD2 (or RNA-associated early-stage antiviral factor) has been shown to be upregulated upon T cell activation, is highly expressed in myeloid cells, binds viral reverse transcripts, and potently restricts HIV-1 infection. RPRD2 is also bound by HIV-1 Vpr and targeted for degradation by the proteasome upon reverse transcription, suggesting RPRD2 impedes reverse transcription and Vpr targeting overcomes this block. RPRD2 is mainly localized to the nucleus and binds RNA, DNA, and DNA:RNA hybrids. RPRD2 has been shown to negatively regulate genome-wide transcription and interact with the HUSH and PAF1 complexes which repress HIV transcription and are implicated in maintenance of HIV latency (PMID: 37882563).

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