Anticorps Monoclonal anti-SAV1

SAV1 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1G1H11

N° de cat : 60903-1-PBS

Synonymes

45 kDa WW domain protein, hWW45, Protein salvador homolog 1, SAV

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Galerie de données de validation

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  WB analysis using 60903-1-Ig (same clone as 60903-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 60903-1-Ig (SAV1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60903-1-PBS in a different storage buffer formulation.

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  WB analysis of HSC-T6 using 60903-1-Ig (same clone as 60903-1-PBS)

  HSC-T6 cells were subjected to SDS PAGE followed by western blot with 60903-1-Ig (SAV1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60903-1-PBS in a different storage buffer formulation.

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  WB analysis of NIH/3T3 using 60903-1-Ig (same clone as 60903-1-PBS)

  NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 60903-1-Ig (SAV1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60903-1-PBS in a different storage buffer formulation.

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Informations sur le produit

60903-1-PBS cible SAV1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: SAV1 Protéine recombinante Ag3441
• Nom complet: salvador homolog 1 (Drosophila)
• Masse moléculaire calculée: 383 aa, 45 kDa
• Poids moléculaire observé: 45 kDa
• Numéro d’acquisition GenBank: BC020537
• Symbole du gène: SAV1
• Identification du gène (NCBI): 60485
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The Salvador family WW domain‐containing 1 (SAV1, also known as WW45) is a human homologue of Salvador that contains two protein‐protein interaction modules known as WW domains and acts as a scaffolding protein (PMID: 28618450). SAV1 belongs to the core kinase components of Hippo signalling pathway for efficient MST1/2 activation. SAV1 represses the growth of colorectal cancer cells by inactivating Akt‐mTOR signalling in a YAP‐dependent manner (PMID: 29063833, 22185343).

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