Anticorps Polyclonal de lapin anti-SCAI

SCAI Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33449-1-PBS

Synonymes

C9orf126, Protein SCAI, Suppressor of cancer cell invasion protein

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Galerie de données de validation

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  WB analysis using 33449-1-AP (same clone as 33449-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33449-1-AP (SCAI antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33449-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33449-1-PBS cible SCAI dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SCAI Protéine recombinante Ag38169
• Nom complet: chromosome 9 open reading frame 126
• Masse moléculaire calculée: 70kDa，606aa
• Poids moléculaire observé: 60 kDa
• Numéro d’acquisition GenBank: NM_001144877.2
• Symbole du gène: C9orf126
• Identification du gène (NCBI): 286205
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SCAI (suppressor of cancer cell invasion) is a conserved protein that regulates invasive cell migration through three-dimensional matrices. SCAI acts on the RhoA-Dia1 signal transduction pathway and localizes in the nucleus, where it binds and inhibits the myocardin-related transcription factor MAL by forming a ternary complex with serum response factor (SRF). Genome-wide expression analysis surprisingly reveals that one of the strongest upregulated genes after suppression of SCAI is beta1-integrin. Decreased levels of SCAI are tightly correlated with increased invasive cell migration, and SCAI is downregulated in several human tumours. Functional analysis of the beta1-integrin gene strongly argues that SCAI is a novel transcriptional cofactor that controls gene expression downstream of Dia1 to dictate changes in cell invasive behaviour (PMID: 19350017).

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