Anticorps Recombinant de lapin anti-SCN4A

SCN4A Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

243036A8

N° de cat : 85698-1-PBS

Synonymes

HYKPP, HYPP, Na(V)1.4, NAC1A, Nav1.4

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Galerie de données de validation

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  WB analysis using 85698-1-RR (same clone as 85698-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85698-1-RR (SCN4A antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85698-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skeletal muscle using 85698-1-RR (same clone as 85698-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 85698-1-RR (SCN4A antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85698-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse skeletal muscle using 85698-1-RR (same clone as 85698-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 85698-1-RR (SCN4A antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85698-1-PBS in a different storage buffer formulation.

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Informations sur le produit

85698-1-PBS cible SCN4A dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: sodium channel, voltage-gated, type IV, alpha subunit
• Masse moléculaire calculée: 208 kDa
• Poids moléculaire observé: 208 kDa
• Numéro d’acquisition GenBank: NM_000334
• Symbole du gène: SCN4A
• Identification du gène (NCBI): 6329
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Sodium channel protein type 4 subunit alpha (SCN4A, also known as Nav1.4) is the pore-forming subunit of the primary sodium channel present in skeletal muscles (PMID: 16193245). Nav1.4 related channelopathies that affect skeletal muscle excitability are dominant diseases classified in two opposite groups as defined by the prevalent clinical symptoms: muscle stiffness and hypertonia (myotonia) episodes [non dystrophic myotonias (NDM)], and muscle weakness resulting in paralysis episodes (periodic paralyses; PP) (PMID: 20237798; 26285000).

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