Anticorps Polyclonal de lapin anti-SCNN1A

SCNN1A Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 28707-1-PBS

Synonymes

ENaCa, Amiloride-sensitive sodium channel subunit alpha, Alpha-NaCH, Alpha-ENaC, Alpha NaCH

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Galerie de données de validation

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  WB analysis using 28707-1-AP (same clone as 28707-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28707-1-AP (SCNN1A antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28707-1-PBS in a different storage buffer formulation.

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Informations sur le produit

28707-1-PBS cible SCNN1A dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SCNN1A Protéine recombinante Ag30063
• Nom complet: sodium channel, nonvoltage-gated 1 alpha
• Masse moléculaire calculée: 76 kDa
• Poids moléculaire observé: 60-70 kDa
• Numéro d’acquisition GenBank: BC006526
• Symbole du gène: SCNN1A
• Identification du gène (NCBI): 6337
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Amiloride-sensitive sodium channel subunit alpha (SCNN1A, also known as Alpha-ENaC and ENaCA) is essential for maintaining sodium homeostasis and is particularly important in the distal nephron and late distal convoluted tubule of the kidney, where aldosterone triggers ENaC activity (PMID: 18086683; 31654198). The ~97 kDa and ~75kDa bands represent the glycosylated and unglycosylated forms of SCNN1A (PMID: 19462466). It also migrated as intact (≈ 75 kDa) and furin-cleaved (≈ 50 kDa) in urinary extracellular vesicles (uEVs) (PMID: 31654198).

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