Anticorps Polyclonal de lapin anti-SCRT1

SCRT1 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31577-1-PBS

Synonymes

SCRT, Scratch 1, hScrt

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Galerie de données de validation

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  WB analysis using 31577-1-AP (same clone as 31577-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31577-1-AP (SCRT1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31577-1-PBS in a different storage buffer formulation.

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Informations sur le produit

31577-1-PBS cible SCRT1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SCRT1 Protéine recombinante Ag36215
• Nom complet: scratch homolog 1, zinc finger protein (Drosophila)
• Poids moléculaire observé: 36 kDa
• Numéro d’acquisition GenBank: BC168377
• Symbole du gène: SCRT1
• Identification du gène (NCBI): 83482
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SCRT1 (Transcriptional repressor scratch 1), which is expressed in many tissues, especially in brain and adrenal gland. In addition, SCRT1 is also expressed in islet β cells, and its expression is related to insulin secretion ability. SCRT1 is a C2H2 zinc finger transcription inhibitor, which can bind to E-box motif. The encoded protein may promote nerve differentiation and may be related to cancer with neuroendocrine characteristics. The functions of SCRT1 in islet β cells include regulating the expression and secretion of insulin and influencing the proliferation of β cells. SCRT1 may control calcineurin /NFAT signaling pathway by affecting the expression of Syt4, Notch1, Nfatc1 and Nfatc2 genes, which is an important regulator of the growth and function of β cells (PMID: 33309639). The molecular weight of SCRT1 is 36 kDa.

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