Anticorps Polyclonal de lapin anti-SENP2

SENP2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29772-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 29772-1-AP (same clone as 29772-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29772-1-AP (SENP2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29772-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 29772-1-AP (same clone as 29772-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 29772-1-AP (SENP2 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29772-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29772-1-PBS cible SENP2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SENP2 Protéine recombinante Ag30728
• Nom complet: SUMO1/sentrin/SMT3 specific peptidase 2
• Masse moléculaire calculée: 68 kDa
• Poids moléculaire observé: 60-68 kDa
• Numéro d’acquisition GenBank: NM_021627
• Symbole du gène: SENP2
• Identification du gène (NCBI): 59343
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SENP2 (Sentrin-specific protease 2), as a protease, catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PMID:15296745). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PMID:20194620, PMID:21965678). It has 2 isoforms with the molecular weight of 66 and 68 kDa.

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