Anticorps Polyclonal de lapin anti-SERPINB2

SERPINB2 Polyclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 16035-1-PBS

Synonymes

---

Galerie de données de validation

• 

  WB analysis using 16035-1-AP (same clone as 16035-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16035-1-AP (SERPINB2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16035-1-PBS in a different storage buffer formulation.

• 

  IP experiment of Jurkat using 16035-1-AP (same clone as 16035-1-PBS)

  IP result of anti-SERPINB2 (IP:16035-1-AP, 4ug; Detection:16035-1-AP 1:300) with Jurkat cells lysate 3600ug. This data was developed using the same antibody clone with 16035-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

16035-1-PBS cible SERPINB2 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SERPINB2 Protéine recombinante Ag8906
• Nom complet: serpin peptidase inhibitor, clade B (ovalbumin), member 2
• Masse moléculaire calculée: 415 aa, 47 kDa
• Poids moléculaire observé: 45-47 kDa
• Numéro d’acquisition GenBank: BC012609
• Symbole du gène: SERPINB2
• Identification du gène (NCBI): 5055
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SerpinB2, a plasminogen activator inhibitor-2 (PAI-2), is a serine protease inhibitor of the serpin superfamily that inactivates tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) (PMID: 7506655). SerpinB2 may have both pro-tumor and anti-tumor effects. High expression of tumor cell-associated SerpinB2 facilitates breast cancer cell survival and metastasis (PMID: 24581498; PMID: 28427146), while SerpinB2 expression by breast cancer cells significantly inhibits metastasis by inhibiting extracellular uPA (PMID: 24644264; PMID: 28346421).

{{ptg:RelatedPrimaryAntibodies}}