Anticorps Recombinant de lapin anti-SESN1

SESN1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250470G1

N° de cat : 86008-1-PBS

Synonymes

EC:1.11.1.-, p53 regulated protein PA26, p53-regulated protein PA26, PA26, SEST1

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Galerie de données de validation

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  WB analysis using 86008-1-RR (same clone as 86008-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86008-1-RR (SESN1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86008-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86008-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86008-1-RR against Human SESN1 were performed. The affinity constant is 1.01 nM.

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Informations sur le produit

86008-1-PBS cible SESN1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: SESN1 Protéine recombinante Ag16462
• Nom complet: sestrin 1
• Masse moléculaire calculée: 551 aa, 64 kDa
• Poids moléculaire observé: 66 kDa
• Numéro d’acquisition GenBank: BC112036
• Symbole du gène: SESN1
• Identification du gène (NCBI): 27244
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Sestrins, including sestrin-1 (PA26), sestrin-2 (Hi95), and sestrin-3, are 48 to 65 kDa cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. Expression of these proteins is regulated by p53, a tumor suppressor protein. Sestrin 1 is implicated in the inhibition of cell growth. It is approximately a 66kDa protein in humans (551 amino acids).

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