Anticorps Polyclonal de lapin anti-SFRS6

SFRS6 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11772-1-PBS

Synonymes

Pre-mRNA-splicing factor SRP55, Serine/arginine-rich splicing factor 6, Splicing factor, arginine/serine-rich 6, SRP55, SRSF6

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Galerie de données de validation

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  WB analysis using 11772-1-AP (same clone as 11772-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11772-1-AP (SFRS6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11772-1-PBS in a different storage buffer formulation.

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Informations sur le produit

11772-1-PBS cible SFRS6 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SFRS6 Protéine recombinante Ag2412
• Nom complet: splicing factor, arginine/serine-rich 6
• Masse moléculaire calculée: 344 aa, 40 kDa
• Poids moléculaire observé: 40 kDa
• Numéro d’acquisition GenBank: BC006832
• Symbole du gène: SFRS6
• Identification du gène (NCBI): 6431
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SR proteins have a characteristic C-terminal Ser/Arg-rich repeat (RS domain) of variable length and constitute a family of highly conserved nuclear phosphoproteins that can function as both essential and alternative pre-mRNA splicing factors [PMID:7556075]. SRFS6 has a pivotal role in the TF exon 5 definition, an event essential for flTF biosynthesis. Besides, up- or down regulation of SRSF6 alters the splicing of several tumor suppressors and oncogenes to generate the oncogenic isoforms and reduce the tumor suppressive isoforms [PMID:23132731].

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