Anticorps Polyclonal de lapin anti-SHANK2

SHANK2 Polyclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27272-1-PBS

Synonymes

SHANK, ProSAP1, KIAA1022, CTTNBP1, CORTBP1

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Galerie de données de validation

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  WB analysis using 27272-1-AP (same clone as 27272-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27272-1-AP (SHANK2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27272-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse brain using 27272-1-AP (same clone as 27272-1-PBS)

  IP result of anti-SHANK2 (IP:27272-1-AP, 4ug; Detection:27272-1-AP 1:1000) with mouse brain tissue lysate 1600 ug. This data was developed using the same antibody clone with 27272-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27272-1-PBS cible SHANK2 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SHANK2 Protéine recombinante Ag26101
• Nom complet: SH3 and multiple ankyrin repeat domains 2
• Masse moléculaire calculée: 159 kDa
• Poids moléculaire observé: 158-200 kDa
• Numéro d’acquisition GenBank: NM_012309
• Symbole du gène: SHANK2
• Identification du gène (NCBI): 22941
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) is also named as CORTBP1, KIAA1022, PROSAP1. SHANK2 code a scaffolding protein located at the postsynaptic membrane of glutamatergic neurons (PMID: 32987185). SHANK2 encodes for a postsynaptic scaffolding protein at glutamatergic synapses in the brain, essential for proper synapse formation, development and plasticity (PMID: 11283303, PMID: 12065602). As SHANK2 directly interacts with IRSp53 (insulin receptor substrate p53), it may be involved in insulin signaling in the brain, making this pathway susceptible to SHANK2 mutations (PMID: 33483523). In the SFARI gene database, SHANK2 is categorized as a high confidence autism risk gene. In addition, SHANK2 has been linked to the pathology of neuropsychiatric (schizophrenia, bipolar disorder) and neurodegenerative disorders (PMID: 33483523).

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