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Anticorps Polyclonal de lapin anti-SHLD3

SHLD3 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30735-1-PBS

Synonymes

FLJ26957, REV7-interacting novel NHEJ regulator 1, RINN1, Shield complex subunit 3, Shieldin complex subunit 3

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using SHLD3 Polyclonal antibody (30735-1-AP)

    WB analysis using 30735-1-AP (same clone as 30735-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30735-1-AP (SHLD3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30735-1-PBS in a different storage buffer formulation.

Informations sur le produit

30735-1-PBS cible SHLD3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène SHLD3 Protéine recombinante Ag32940
Nom complet SHLD3
Masse moléculaire calculée29 kDa
Poids moléculaire observé28-70 kDa
Symbole du gène SHLD3
Identification du gène (NCBI) 112441434
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SHLD3 (shieldin complex subunit 3), also known as RINN1 or CTC-534A2.2. It is located in Chromosome and expressed in monocyte. The gene is a component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). It has been found that the proper function of MAD2L2 in shieldin requires its dimerization, and the interaction between MAD2L2 and SHLD3 is mediated and accelerated by SHLD2. The dimerization defect MAD2L2 damages the assembly of shieldin and cannot promote the NHEJ. In addition, the dimerization of MAD2L2 and the existence of SHLD3 allow shieldin to interact with TRIP13 ATPase (PMID: 34521823). The calculated molecular weight of SHLD3 is 28 kDa, the antibody can recognize the 70kDa band, which may be related to the interaction between MAD2L2 and SHLD3 as a dimer in shieldin complex.

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