Anticorps Recombinant de lapin anti-SHOC2/Sur-8

SHOC2/Sur-8 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242343E6

N° de cat : 84917-5-PBS

Synonymes

SHOC2, sur-8, KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc 2 homolog

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Galerie de données de validation

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  WB analysis using 84917-5-RR (same clone as 84917-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84917-5-RR (SHOC2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84917-5-PBS in a different storage buffer formulation.

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Informations sur le produit

84917-5-PBS cible SHOC2/Sur-8 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: SHOC2/Sur-8 Protéine recombinante Ag11754
• Nom complet: soc-2 suppressor of clear homolog (C. elegans)
• Masse moléculaire calculée: 582 aa, 65 kDa
• Poids moléculaire observé: 65 kDa
• Numéro d’acquisition GenBank: BC050445
• Symbole du gène: SHOC2/Sur-8
• Identification du gène (NCBI): 8036
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SHOC2 is also named as Sur-8. The SHOC2 protein, along with MRAS and PP1C, forms a high affinity, heterotrimeric holoenzyme that activates RAF kinases by dephosphorylating a specific phosphoserine (PMID: 37074066). SHOC2, a key protein mediating the Ras-Raf-ERK pathway, could act as a scaffolding protein to facilitate the activation of the pathway by mediating the interaction of key components of the pathway (PMID: 37170083). The scaffold protein Shoc2 is a critical modulator of ERK1/2 signals, and mutations in the shoc2 gene lead to the human developmental disease known as Noonan-like syndrome with loose anagen hair (NSLH) (PMID: 36265687).

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