Anticorps Polyclonal de lapin anti-SIAE

SIAE Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

N° de cat : 14566-1-PBS

Synonymes

Sialate O-acetylesterase, LSE, H-Lse, H Lse, EC:3.1.1.53

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Galerie de données de validation

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  WB analysis using 14566-1-AP (same clone as 14566-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 14566-1-AP (SIAE antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14566-1-PBS in a different storage buffer formulation.

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Informations sur le produit

14566-1-PBS cible SIAE dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SIAE Protéine recombinante Ag6143
• Nom complet: sialic acid acetylesterase
• Masse moléculaire calculée: 58 kDa
• Poids moléculaire observé: 62-70 kDa
• Numéro d’acquisition GenBank: BC068450
• Symbole du gène: SIAE
• Identification du gène (NCBI): 54414
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Sialic acids as terminal sugars of N- and O-glycosylated macromolecules are decisive for the functions of glycoconjugates both in soluble form and integrated into cell membranes .The two enzymes responsible for acetylation and de-acetylation have been described as sialate O-acetyltransferase (SOAT) and sialate O-acetylesterase (SIAE), respectively. SIAE deacetylates α(2-6)-linked sialic acid on N-linked glycans of BCR, allowing the interaction with CD22, that functions in vivo as an inhibitor of BCR signaling. (PMID: 26022516)

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