Anticorps Monoclonal anti-SIRT6

• Phare
• Validé par KD/KO

SIRT6 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2H4G8

N° de cat : 67510-1-PBS

Synonymes

2H4G8, EC:2.3.1.-, EC:2.3.1.286, EC:2.4.2.-, hSIRT6

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Galerie de données de validation

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  WB analysis using 67510-1-Ig (same clone as 67510-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67510-1-Ig (SIRT6 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

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  WB analysis of Jurkat using 67510-1-Ig (same clone as 67510-1-PBS)

  WB result of SIRT6 antibody (67510-1-Ig; 1:4000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SIRT6 transfected Jurkat cells. This data was developed using the same antibody clone with 67510-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67510-1-PBS cible SIRT6 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: SIRT6 Protéine recombinante Ag24103
• Nom complet: sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
• Masse moléculaire calculée: 39 kDa
• Poids moléculaire observé: 40 kDa
• Numéro d’acquisition GenBank: BC028220
• Symbole du gène: SIRT6
• Identification du gène (NCBI): 51548
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).

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