Anticorps Polyclonal de lapin anti-SKA2

SKA2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33333-1-PBS

Synonymes

FAM33A, Protein FAM33A, Spindle and kinetochore-associated protein 2

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Galerie de données de validation

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  WB analysis using 33333-1-AP (same clone as 33333-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33333-1-AP (SKA2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33333-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33333-1-PBS cible SKA2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SKA2 Protéine recombinante Ag37037
• Nom complet: family with sequence similarity 33, member A
• Masse moléculaire calculée: 121 aa, 14 kDa
• Poids moléculaire observé: 15 kDa
• Numéro d’acquisition GenBank: BC017873
• Symbole du gène: FAM33A
• Identification du gène (NCBI): 348235
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SKA2 (spindle and KT associated 2), also referred to as FAM33A (family with sequence similarity 33, member A), is a recently identified gene involved in cell cycle regulation, and growing evidence is implicating its roles in tumorigenesis and psychiatric disorders. It has been demonstrated that SKA2, along with its coworkers SKA1 and SKA3, constitutes the SKA complex which plays a critical role in the maintenance of the metaphase plate and/or spindle checkpoint silencing during mitosis. SKA2 is over-expressed both in cancer cell lines and clinical samples including small cell lung cancer and breast cancer, whereas downregulation of SKA2 is associated with depression and suicidal ideation. The expression of SKA2 is regulated by transcription factors including NF-κΒ and CREB, miRNAs as well as DNA methylation (PMID: 30906829).

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