Anticorps Recombinant de lapin anti-SLAMF7/CD319

SLAMF7/CD319 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242629G1

N° de cat : 98342-1-PBS

Synonymes

CD319, Leukocyte cell-surface antigen, Novel Ly9, SLAM family member 7, Slamf7

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98342-1-RR (same clone as 98342-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse SLAMF7/CD319 Rabbit RecAb (98342-1-RR, Clone:242629G1) , or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11) and PE-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were then stained with CoraLite® Plus 488 Anti-Mouse CD19. Cells were not fixed. This data was developed using the same antibody clone with 98342-1-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98342-1-RR (same clone as 98342-1-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse SLAMF7/CD319 Rabbit RecAb (98342-1-RR, Clone:242629G1)(red) , or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11)(blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L).Cells were not fixed.Cells were not fixed. This data was developed using the same antibody clone with 98342-1-PBS in a different storage buffer formulation.

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Informations sur le produit

98342-1-PBS cible SLAMF7/CD319 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: SLAM family member 7
• Masse moléculaire calculée: 37 kDa
• Numéro d’acquisition GenBank: NM_144539.5
• Symbole du gène: Slamf7
• Identification du gène (NCBI): 75345
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Signaling lymphocyte activation molecule (SLAM) family receptors is a group of type I transmembrane receptors belonging to the immunoglobulin superfamily (PMID: 37251372). The SLAM family contains nine members that contain an extracellular segment comprising two or four Ig-like domains (V-like variable and C2-like constant), a transmembrane region and a cytoplasmic tail (PMID: 29662641). They are involved in various physiological and pathological processes, including the regulation of immunological responses and the route of viral entry. SLAMF7, also known as CS1, CRACC or CD319, is expressed on NK cells, CD8+ T lymphocytes, B lymphocytes, and mature dendritic cells (PMID: 28861320). It exerts both activating and inhibitory effects depending on the expression status of SAP or EAT-2. SLAMF7 is overexpressed in multiple myeloma and makes it a target for immunotherapy (PMID: 28861320).

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