Anticorps Polyclonal de lapin anti-SLC28A3

SLC28A3 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18182-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 18182-1-AP (same clone as 18182-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18182-1-AP (SLC28A3 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18182-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 18182-1-AP (same clone as 18182-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 18182-1-AP (SLC28A3 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18182-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 18182-1-AP (same clone as 18182-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 18182-1-AP (SLC28A3 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18182-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 18182-1-AP (same clone as 18182-1-PBS)

  Immunofluorescent analysis of (-20°C Methanol) fixed HepG2 cells using SLC28A3 antibody (18182-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 18182-1-PBS in a different storage buffer formulation.

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Informations sur le produit

18182-1-PBS cible SLC28A3 dans les applications de WB, IHC, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SLC28A3 Protéine recombinante Ag12887
• Nom complet: solute carrier family 28 (sodium-coupled nucleoside transporter), member 3
• Masse moléculaire calculée: 691 aa, 77 kDa
• Poids moléculaire observé: 70-75 kDa
• Numéro d’acquisition GenBank: BC093821
• Symbole du gène: SLC28A3
• Identification du gène (NCBI): 64078
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SLC28A3 (Solute carrier family 28 member 3), also named CNT3, has sodium-dependent, pyrimidine- and purine-selective (PMID: 11032837, PMID: 15861042, PMID: 16446384, PMID: 17140564, PMID: 21998139). It is involved in the homeostasis of endogenous nucleosides (PMID: 11032837, PMID: 15861042). SLC28A3 is able to transports uridine, gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (PMID: 21795683, PMID: 11032837, PMID: 17140564). SLC28A3, the human concentrative nucleoside transporter, plays a role in mediating the cellular entry of a broad array of physiological nucleosides and synthetic anticancer nucleoside analog drugs (PMID: 15738947). Variants in SLC28A3 and UGT1A6 act as genetic markers predictive of anthracycline-induced cardiotoxicity (PMID: 23441093).

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