Anticorps Polyclonal de lapin anti-SLC7A11/xCT

SLC7A11/xCT Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications(1)

N° de cat : 32384-1-AP

Synonymes

Amino acid transport system xc-, Cystine/glutamate transporter, Slc7a11, Solute carrier family 7 member 11, Subtle gray protein

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Galerie de données de validation

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  WB analysis using 32384-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 32384-1-AP (SLC7A11/xCT antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules HeLa non bouillies, cellules HepG2 non bouillies, tissu cérébral de souris non bouilli

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:4000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• IF: See 1 publications below

Informations sur le produit

32384-1-AP cible SLC7A11/xCT dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Réactivité citée: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SLC7A11/xCT Protéine recombinante Ag38215
• Nom complet: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
• Masse moléculaire calculée: 55 kDa
• Poids moléculaire observé: 35-40 kDa
• Numéro d’acquisition GenBank: NM_011990
• Symbole du gène: Slc7a11
• Identification du gène (NCBI): 26570
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

SLC7A11 (also known as xCT) is a membrane transporter involved in cysteine uptake. It promotes glutathione synthesis through cystine uptake and the concomitant release of glutamate. This, in turn, protects cells from oxidative stress, maintains cellular redox balance, and prevents cell death induced by lipid peroxidation. SLC7A11 has been identified as a potential target for cancer therapeutics. It is overexpressed in multiple malignant tumors and is closely associated with the growth, prognosis, metastasis, and treatment response of various cancers, including lung cancer. 32384-1-AP recognizes the 35-40 kDa protein similar to the paper published (PMID: 36747082).

Publications

Species	Application	Title
mouse	IF	Toxicology; Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis; Authors - Runyang Hong

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