Anticorps Polyclonal de lapin anti-SMAD6

SMAD6 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 18342-1-PBS

Synonymes

hSMAD6, MADH6, Mothers against DPP homolog 6, SMAD family member 6

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Galerie de données de validation

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  WB analysis using 18342-1-AP (same clone as 18342-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18342-1-AP (SMAD6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18342-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 18342-1-AP (same clone as 18342-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18342-1-AP (SMAD6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18342-1-PBS in a different storage buffer formulation.

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Informations sur le produit

18342-1-PBS cible SMAD6 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SMAD6 Protéine recombinante Ag13128
• Nom complet: SMAD family member 6
• Masse moléculaire calculée: 53 kDa
• Poids moléculaire observé: 52 kDa
• Numéro d’acquisition GenBank: BC012986
• Symbole du gène: SMAD6
• Identification du gène (NCBI): 4091
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SMAD6 is an intracellular signal transduction protein that belongs to the SMAD protein family. It acts as a negative regulator in the transforming growth factor-beta (TGF-β) signaling pathway, binding to TGF-β receptors and inhibiting the phosphorylation of SMAD2/SMAD3, thereby blocking the transmission of TGF-β signals. Additionally, SMAD6 is involved in the regulation of the bone morphogenetic protein (BMP) signaling pathway, affecting cell proliferation, differentiation, and apoptosis. During development, SMAD6 is crucial for the formation of bones and cartilage. Its abnormal expression is associated with various diseases, including skeletal developmental abnormalities and certain types of cancer.

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