Anticorps Recombinant de lapin anti-SNRNP200

SNRNP200 Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242550D10

N° de cat : 84992-5-PBS

Synonymes

242550D10, Activating signal cointegrator 1 complex subunit 3-like 1, ASCC3L1, BRR2, EC:3.6.4.13

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Galerie de données de validation

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  WB analysis using 84992-5-RR (same clone as 84992-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84992-5-RR (SNRNP200 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84992-5-PBS in a different storage buffer formulation.

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  IHC staining of human placenta using 84992-5-RR (same clone as 84992-5-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 84992-5-RR (SNRNP200 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84992-5-PBS in a different storage buffer formulation.

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  IHC staining of human placenta using 84992-5-RR (same clone as 84992-5-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 84992-5-RR (SNRNP200 antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84992-5-PBS in a different storage buffer formulation.

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Informations sur le produit

84992-5-PBS cible SNRNP200 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: SNRNP200 Protéine recombinante Ag20748
• Nom complet: small nuclear ribonucleoprotein 200kDa (U5)
• Masse moléculaire calculée: 494 aa, 57 kDa
• Poids moléculaire observé: 200-245 kDa
• Numéro d’acquisition GenBank: BC001417
• Symbole du gène: SNRNP200
• Identification du gène (NCBI): 23020
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SNRNP200 (small nuclear ribonucleoprotein 200kDa (U5)), also known as HELIC2, ASCC3L1 or BRR2, is a 2,136 amino acid protein that localizes to the nucleus and contains two SEC63 domains, two helicase C-terminal domains and two helicase ATP-binding domains. Existing as multiple alternatively spliced isoforms, HELIC2 functions as an RNA helicase that is thought to promote specific RNA-RNA conformational changes which are important in the second step of RNA splicing. The gene encoding HELIC2 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the chromosome 2-localized ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes, hich also map to chromosome 2. The observed molecular weight of SNRNP200 is 200-245kd.

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