Anticorps Polyclonal de lapin anti-SNTA1

SNTA1 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 13131-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 13131-1-AP (same clone as 13131-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 13131-1-AP (SNTA1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13131-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 13131-1-AP (same clone as 13131-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 13131-1-AP (SNTA1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13131-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 13131-1-AP (same clone as 13131-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 13131-1-AP (SNTA1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13131-1-PBS in a different storage buffer formulation.

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Informations sur le produit

13131-1-PBS cible SNTA1 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SNTA1 Protéine recombinante Ag3820
• Nom complet: syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
• Masse moléculaire calculée: 505 aa, 54 kDa
• Poids moléculaire observé: 54 kDa
• Numéro d’acquisition GenBank: BC026215
• Symbole du gène: SNTA1
• Identification du gène (NCBI): 6640
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SNTA1, also known as Syntrophin 1, SNT1, is cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. SNTA1 is a signal-transducing adaptor protein and serves as a scaffold for various signaling molecules. Alpha-1 syntrophin contains a PDZ domain, two Pleckstrin homology domains, and a 'syntrophin unique' domain. SNTA1 is the high expression in skeletal muscle and heart (PMID: 8576247, 8612778,). The PDZ domain of SNTA1 has been reported to bind to the C-terminal domain of murine cardiac voltage-gated sodium channels (SkM2) causing altering ion channel activity leading to Long QT syndrome(PMID 19684871, 19862833).

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