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Anticorps Recombinant de lapin anti-SOCS3

SOCS3 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242809D7

N° de cat : 85155-4-PBS

Synonymes

242809D7, ATOD4, CIS3, CIS-3, Cytokine-inducible SH2 protein 3

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using SOCS3 Recombinant antibody (85155-4-RR)

    WB analysis using 85155-4-RR (same clone as 85155-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85155-4-RR (SOCS3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85155-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85155-4-RR

    Affinity and Kinetic Characterization of 85155-4-RR

    Biolayer interferometry (BLl) kinetic assays of 85155-4-RR against Human SOCS3 were performed. The affinity constant is below 1 pM.

Informations sur le produit

85155-4-PBS cible SOCS3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène SOCS3 Protéine recombinante Ag5170
Nom complet suppressor of cytokine signaling 3
Masse moléculaire calculée 25 kDa
Poids moléculaire observé 25-30 kDa
Numéro d’acquisition GenBankBC060858
Symbole du gène SOCS3
Identification du gène (NCBI) 9021
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The suppressor of cytokine signaling (SOCS) family proteins are negative feedback system that inhibits cytokine signal transduction. One of the SOCS family, SOCS3, also named CIS3 and SSI3, is involved in inhibition of JAK/STAT pathway which regulates IL-6 signaling in vivo. SOCS3 can be rapidly trigger by a number of factors including interleukins, IFN-gamma and TNF-alpha. Pathology such as inflammatory response, wound repair and obesity and so on have been linked to SOCS3. Observed MW of SOCS3 is from 22-30 kDa(PMID: 24827536,PMID: 26260587, PMID: 26797799).

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