Anticorps Polyclonal de lapin anti-SOCS6

SOCS6 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 27343-1-PBS

Synonymes

CIS 4, CIS4, CIS-4, Cytokine-inducible SH2 protein 4, HSPC060

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Galerie de données de validation

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  WB analysis using 27343-1-AP (same clone as 27343-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 27343-1-AP (SOCS6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

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  IP experiment of NIH/3T3 using 27343-1-AP (same clone as 27343-1-PBS)

  IP result of anti-SOCS6 (IP:27343-1-AP, 4ug; Detection:27343-1-AP 1:1500) with NIH/3T3 cells lysate 1200 ug. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

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  IP experiment of human placenta using 27343-1-AP (same clone as 27343-1-PBS)

  IP result of anti-SOCS6 (IP:27343-1-AP, 4ug; Detection:27343-1-AP 1:1500) with human placenta tissue lysate 960 ug. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon using 27343-1-AP (same clone as 27343-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

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  IHC staining of human colon using 27343-1-AP (same clone as 27343-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse colon using 27343-1-AP (same clone as 27343-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse colon using 27343-1-AP (same clone as 27343-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

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Informations sur le produit

27343-1-PBS cible SOCS6 dans les applications de WB, IHC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SOCS6 Protéine recombinante Ag25594
• Nom complet: suppressor of cytokine signaling 6
• Masse moléculaire calculée: 60 kDa
• Poids moléculaire observé: 60-75 kDa
• Numéro d’acquisition GenBank: BC020082
• Symbole du gène: SOCS6
• Identification du gène (NCBI): 9306
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SOCS6 (Suppressor of cytokine signaling 6) is also named as CIS4 and SOCS4. SOCS6 is one of eight members of the SOCS family of proteins. SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces apoptosis by targeting mitochondrial proteins (PMID: 25172101). SOCS6 is widely expressed in many tissues and is found to be downregulated in many cancers including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, stomach cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer (PMID: 25172101). In addition to its molecular weight of 60 kDa, SOCS6 has a 70 kDa isoform (PMID: 34169835, PMID: 22125600).

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