Anticorps Polyclonal de lapin anti-SOX4

SOX4 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

Publications(5)

N° de cat : 27414-1-AP

Synonymes

Transcription factor SOX-4, EVI16, CSS10

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Galerie de données de validation

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  WB analysis using 27414-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 27414-1-AP (SOX4 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules A549, cellules HepG2, cellules HL-60, cellules K-562, cellules MDA-MB-231

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:3000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 5 publications below

Informations sur le produit

27414-1-AP cible SOX4 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SOX4 Protéine recombinante Ag26583
• Nom complet: SRY (sex determining region Y)-box 4
• Masse moléculaire calculée: 474 aa, 47 kDa
• Poids moléculaire observé: 47 kDa
• Numéro d’acquisition GenBank: BC072668
• Symbole du gène: SOX4
• Identification du gène (NCBI): 6659
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors that play key roles in the regulation of stemness, differentiation, progenitor cell development, and multiple developmental pathways. A single-exon gene encodes the SOX4 protein and contains a highly conserved high-mobility group (HMG) DNA binding domain related to the TCF/LEF family of transcription factors that play important roles in the Wnt pathway. SOX4 is expressed in stem cells, and modulates stem cell activation and likely also plays a role in stem cell maintenance, possibly through activation of expression of SOX2 (PMID: 23764001, 31445218). The calculated molecular weight of SOX4 is 47 kDa.

Publications

Species	Application	Title
human	WB	Adv Sci (Weinh); DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication; Authors - Caiyue Ren
human	WB	Adv Sci (Weinh); Exosomal CCT6A Secreted by Cancer-Associated Fibroblasts Interacts with β-Catenin to Enhance Chemoresistance and Tumorigenesis in Gastric Cancer; Authors - Hui Sun
human	WB	Int J Mol Sci; Preclinical Repurposing of Sitagliptin as a Drug Candidate for Colorectal Cancer by Targeting CD24/CTNNB1/SOX4-Centered Signaling Hub; Authors - Jing-Wen Shih
human	WB	Oral Dis; USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination; Authors - Chang Liu
human	WB	Cell Signal; The roles and mechanisms of TGFB1 in acute myeloid leukemia chemoresistance; Authors - Xue Liang

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