Anticorps Polyclonal de lapin anti-SOX9

SOX9 Polyclonal Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain et plus (2)

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications(4)

N° de cat : 55152-1-AP

Synonymes

Transcription factor SOX-9, Transcription factor SOX 9, SRA1, CMPD1, CMD1

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Galerie de données de validation

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  WB analysis using 55152-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 55152-1-AP (SOX9 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules HepG2, TT cells

Dilution recommandée

• Western Blot (WB): WB : 1:1000-1:6000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 3 publications below
• IF: See 1 publications below

Informations sur le produit

55152-1-AP cible SOX9 dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Réactivité citée: rat, Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: SRY (sex determining region Y)-box 9
• Masse moléculaire calculée: 56 kDa
• Poids moléculaire observé: 56 kDa, 68-75 kDa
• Numéro d’acquisition GenBank: NM_000346
• Symbole du gène: SOX9
• Identification du gène (NCBI): 6662
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

SOX9, also named as Transcription factor SOX-9, is a 509 amino acid protein. Sex-determining region Y (SRY)-box 9 protein (SOX9) is a member of the SOX family of transcription factors (TFs) which are developmental regulators that possess high mobility group (HMG) box DNA binding and transactivation domains. It participates in a variety of functions, such as lineage restriction and terminal diferentiation, through precise temporal and spatial expression patterns that difer between particular cell types and tissues. SOX9 gene has been implicated in different types of cancer as an oncogene; however, it also may behave as a tumor suppressor. SOX9 can be ubiquitinated or SUMOylated to higher molecular weight (PMID: 24155239; 16307912; 16554309; 32070068)

Publications

Species	Application	Title
rat	WB	J Craniofac Surg; FSTL1 Can Be a Promising Target in TMJ Osteoarthritis via Regulating Chondrocyte Mitophagy and Apoptosis; Authors - Fangjie Li
mouse	WB	Nat Commun; Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice; Authors - Dongmei Chi
human	IF	Tissue Cell; Expression pattern of RNA demethylase ALKBH5 in fetal and adult human testis; Authors - Fang Fang
human	WB	Nat Commun; Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitors; Authors - Jingfei Xiong

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