• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Anticorps Recombinant de lapin anti-SPINT1/HAI-1

SPINT1/HAI-1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250560F1

N° de cat : 86138-1-PBS

Synonymes

HAI 1, HAI-1, SPINT1, HAI, HAI1

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using SPINT1/HAI-1 Recombinant antibody (86138-1-RR)

    WB analysis using 86138-1-RR (same clone as 86138-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86138-1-RR (SPINT1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86138-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of MCF-7 cells using SPINT1/HAI-1 Recombinant antibody (86138-1-RR)

    WB analysis of MCF-7 using 86138-1-RR (same clone as 86138-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 86138-1-RR (SPINT1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86138-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using SPINT1/HAI-1 Recombinant antibody (86138-1-RR)

    WB analysis using 86138-1-RR (same clone as 86138-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86138-1-RR (SPINT1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86138-1-PBS in a different storage buffer formulation.

Informations sur le produit

86138-1-PBS cible SPINT1/HAI-1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène SPINT1/HAI-1 Protéine recombinante Eg3131
Nom complet serine peptidase inhibitor, Kunitz type 1
Masse moléculaire calculée58 kDa
Poids moléculaire observé58-70 kDa
Numéro d’acquisition GenBankNM_181642.2
Symbole du gène HAI-1
Identification du gène (NCBI) 6692
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is also named as SPINT1 and Kunitz-type protease inhibitor 1. HAI-1 is critical to control matriptase proteolytic activity (PMID: 25310042). HAI-1 inhibits matriptase activity through forming complex with activated matriptase (PMID: 30370662). matriptase, HAI‐1 also binds to and inhibits a variety of serine proteases including of hepsin, plasmin, prostasin, TMPRSS13 and HAT. HAI-1 as a cell-autonomous tumor suppressor that negatively regulates the HGF pathway (PMID: 25925948). HAI-1 is inhibitor of HGFAC (PMID: 9045658). HAI-1 inhibits serine protease activity of ST14/matriptase in vitro (PMID: 28710277). HAI-1 inhibits serine protease activity of TMPRSS13, via the BPTI/Kunitz inhibitor 1 domain (PMID: 20977675). HAI-1 expression is reduced in many cancer types, which is implicated in the progression of cancer and is associated with a worse prognosis in cancer patients (PMID: 30370662).

{{ptg:RelatedPrimaryAntibodies}}