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Anticorps Polyclonal de lapin anti-SPP2

SPP2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30922-1-PBS

Synonymes

SPP24, Spp 24, Secreted phosphoprotein 24, Secreted phosphoprotein 2

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using SPP2 Polyclonal antibody (30922-1-AP)

    WB analysis using 30922-1-AP (same clone as 30922-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30922-1-AP (SPP2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30922-1-PBS in a different storage buffer formulation.

Informations sur le produit

30922-1-PBS cible SPP2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène SPP2 Protéine recombinante Ag29299
Nom complet secreted phosphoprotein 2, 24kDa
Masse moléculaire calculée 24 kDa
Poids moléculaire observé24 kDa
Numéro d’acquisition GenBankNM_006944
Symbole du gène SPP2
Identification du gène (NCBI) 6694
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SPP2 (Secreted phosphoprotein 24), also known as SPP24. SPP2 is a secreted phosphoprotein, which was originally isolated and purified from bovine bone density. It is widely distributed in the body, mainly produced in the liver and transported to other tissues. SPP2 is expressed in many tissues, especially in the liver. Studies have shown that the expression level of SPP2 is up-regulated in liver cirrhosis. In addition, the expression of SPP2 is significantly related to many genes, including APOA1, SLC2A2 and TTR (PMID: 38448371). SPP2 has many biological functions, including: it can inhibit the activity of cysteine protease, participate in bone formation, inhibit calcification, and regulate BMP/TGF-β signaling pathway. SPP2 may be a tumor suppressor, which inhibits the development of HCC by inhibiting BMP/TGF-β signaling pathway. The molecular weight of SPP2 is 24 kDa.

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