Anticorps Recombinant de lapin anti-SRPK2

SRPK2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242935B1

N° de cat : 85613-5-PBS

Synonymes

EC:2.7.11.1, Serine/arginine-rich protein-specific kinase 2, SFRS protein kinase 2, SFRSK2, SR protein specific kinase 2

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Galerie de données de validation

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  WB analysis using 85613-5-RR (same clone as 85613-5-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85613-5-RR (SRPK2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85613-5-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 85613-5-RR

  Biolayer interferometry (BLl) kinetic assays of 85613-5-RR against Human SRPK2 were performed. The affinity constant is 4.16 nM.

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Informations sur le produit

85613-5-PBS cible SRPK2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: SRPK2 Protéine recombinante Ag17885
• Nom complet: SFRS protein kinase 2
• Masse moléculaire calculée: 688 aa, 78 kDa
• Poids moléculaire observé: 105-110 kDa
• Numéro d’acquisition GenBank: BC035214
• Symbole du gène: SRPK2
• Identification du gène (NCBI): 6733
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SRPK2, also named as serine/arginine protein kinase 2 and SFRSK2, belongs to SR protein-specific kinase family which phosphorylate the serine/arginine domain containing proteins in the nuclear speckles to mediate pre-mRNA splicing (PMID: 22854045). In addition to its major role as kinase for the phosphorylation of SR proteins, SRPK2 is involved in cell cycle regulation and cell apoptosis (PMID: 19592491). SRPK2 promotes the proliferation and migration of the colon cancer cells. It has been reported to be regulated in several cancer types (PMID: 27041240). It has 2 isoforms with the calculated molecular mass of 77-79 kDa, and the apparent molecular mass of 105-115 kDa due to posttranslational modification (PMID: 12134018, 16122776).

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