Anticorps Polyclonal de lapin anti-SRR

SRR Polyclonal Antibody for WB, IP, IHC, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, IP, ELISA

Conjugaison

Non conjugué

Publications(2)

N° de cat : 17955-1-AP

Synonymes

ILV1, ISO1, serine racemase, SRR

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Galerie de données de validation

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  WB analysis of mouse brain using 17955-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 17955-1-AP (SRR Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

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  WB analysis of mouse brain using 17955-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 17955-1-AP (SRR Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

• 

  WB analysis of rat brain using 17955-1-AP

  rat brain tissue were subjected to SDS PAGE followed by western blot with 17955-1-AP (SRR Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  WB analysis of mouse brain using 17955-1-AP

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 17955-1-AP (SRR Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

• 

  IP experiment of mouse brain using 17955-1-AP

  IP result of anti-SRR (IP:17955-1-AP, 4ug; Detection:17955-1-AP 1:600) with mouse brain tissue lysate 4000 ug.

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  IHC staining of human kidney using 17955-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 17955-1-AP (SRR Antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human kidney using 17955-1-AP

  Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 17955-1-AP (SRR Antibody) at dilution of 1:50 (under 40x lens).

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  IHC staining of human heart using 17955-1-AP

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 17955-1-AP (SRR Antibody) at dilution of 1:50 (under 10x lens).

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  IHC staining of human heart using 17955-1-AP

  Immunohistochemical analysis of paraffin-embedded human heart tissue slide using 17955-1-AP (SRR Antibody) at dilution of 1:50 (under 40x lens).

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Applications testées

• Résultats positifs en WB: tissu cérébral de souris, tissu cérébral de rat
• Résultats positifs en IP: tissu cérébral de souris,
• Résultats positifs en IHC: tissu rénal humain, tissu cardiaque humain; il est suggéré de démasquer l'antigène avec un tampon de TE buffer pH 9.0; (*) À défaut, 'le démasquage de l'antigène peut être 'effectué avec un tampon citrate pH 6,0.

Dilution recommandée

• Western Blot (WB): WB : 1:500-1:2000
• Immunoprécipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
• Immunohistochimie (IHC): IHC : 1:20-1:200

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Applications publiées

• WB: See 2 publications below

Informations sur le produit

17955-1-AP cible SRR dans les applications de WB, IHC, IP, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SRR Protéine recombinante Ag12449
• Nom complet: serine racemase
• Masse moléculaire calculée: 340 aa, 37 kDa
• Poids moléculaire observé: 37 kDa
• Numéro d’acquisition GenBank: BC074728
• Symbole du gène: SRR
• Identification du gène (NCBI): 63826
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

SRR(serine racemase) is a 37 kDa protein and belongs to the serine/threonine dehydratase family. It plays a role in neuronal activity and a potential biological role in the regulation of N-methyl-D-aspartate (NMDA) receptor activity in these peripheral organs as well. SRR catalyzes the racemization between l- and d-serine.

Publications

Species	Application	Title
mouse	WB	J Neurosci; Selective ablation of Sod2 in astrocytes induces sex-specific effects on cognitive function, D-serine availability, and astrogliosis.; Authors - Matthew P Baier
mouse	WB	Prog Neuropsychopharmacol Biol Psychiatry; Probing cognitive flexibility in Shank2-deficient mice: Effects of D-cycloserine and NMDAR signaling hub dynamics; Authors - Samia Afzal

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