Anticorps Recombinant de lapin anti-STIM2

STIM2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250016E8

N° de cat : 85727-1-PBS

Synonymes

KIAA1482, Stromal interaction molecule 2

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Galerie de données de validation

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  WB analysis using 85727-1-RR (same clone as 85727-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85727-1-RR (STIM2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85727-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 85727-1-RR

  Biolayer interferometry (BLl) kinetic assays of 85727-1-RR against Human STIM2 were performed. The affinity constant is 0.774 nM.

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Informations sur le produit

85727-1-PBS cible STIM2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: STIM2 Protéine recombinante Ag15530
• Nom complet: stromal interaction molecule 2
• Masse moléculaire calculée: 754 aa, 85 kDa
• Poids moléculaire observé: 85-115 kDa
• Numéro d’acquisition GenBank: BC146661
• Symbole du gène: STIM2
• Identification du gène (NCBI): 57620
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

STIM2, also named as KIAA1482, functions as a highly sensitive Ca2+ sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca2+-influx. Regulates basal cytosolic and endoplasmic reticulum Ca2+ concentrations. Upon mild variations of the endoplasmic reticulum Ca2+ concentration, STIM2 translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca2+ release-activated Ca2+ (CRAC) channels ORAI1, ORAI2 and ORAI3. STIM2 may inhibit STIM1-mediated Ca2+ influx. STIM2 has 2 isoforms 105kd and 115kd with Differential levels of phosphorylation.

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