Anticorps Recombinant de lapin anti-STT3A

STT3A Recombinant Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

ELISA

Conjugaison

Non conjugué

CloneNo.

230426B10

N° de cat : 83077-4-RR

Synonymes

ITM1, Integral membrane protein 1, EC:2.4.99.18, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, B5

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Galerie de données de validation

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  Affinity and Kinetic Characterization of 83077-4-RR

  Biolayer interferometry (BLl) kinetic assays of 83077-4-RR against Human STT3A were performed. The affinity constant is 9.73 nM.

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Informations sur le produit

83077-4-RR cible STT3A dans les applications de ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: STT3A Protéine recombinante Ag31994
• Nom complet: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
• Masse moléculaire calculée: 705 aa, 81 kDa
• Numéro d’acquisition GenBank: BC020965
• Symbole du gène: STT3A
• Identification du gène (NCBI): 3703
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

STT3A, also named as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A, is a 705 amino acid prtein, which belongs to the STT3 family. STT3A is expressed at high levels in placenta, liver, muscle and pancreas, and at very low levels in brain, lung and kidney. STT3A is a catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A.

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