Anticorps Polyclonal de lapin anti-SUZ12

• Phare
• Validé par KD/KO

SUZ12 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat

Applications

WB, IHC, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20366-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 20366-1-AP (same clone as 20366-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 20366-1-AP (SUZ12 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293 using 20366-1-AP (same clone as 20366-1-PBS)

  WB result of SUZ12 antibody (20366-1-AP; 1:1200; incubated at room temperature for 1.5 hours) with sh-Control and sh-SUZ12 transfected HEK-293 cells. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IP experiment of HeLa using 20366-1-AP (same clone as 20366-1-PBS)

  IP result of anti-SUZ12 (IP:20366-1-AP, 4ug; Detection:20366-1-AP 1:500) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IP experiment of HeLa using 20366-1-AP (same clone as 20366-1-PBS)

  IP result of anti-SUZ12 (IP:20366-1-AP, 4ug; Detection:20366-1-AP 1:500) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:400. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:100. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:100. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:200. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:200. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human breast cancer using 20366-1-AP (same clone as 20366-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 20366-1-AP (SUZ12 Antibody) at dilution of 1:400. This data was developed using the same antibody clone with 20366-1-PBS in a different storage buffer formulation.

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Informations sur le produit

20366-1-PBS cible SUZ12 dans les applications de WB, IHC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: suppressor of zeste 12 homolog (Drosophila)
• Masse moléculaire calculée: 83 kDa
• Poids moléculaire observé: 80-90 kDa
• Numéro d’acquisition GenBank: NM_015355
• Symbole du gène: SUZ12
• Identification du gène (NCBI): 23512
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SUZ12, also termed CHET9, JJAZ1 or KIAA0160, belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. It is a polycomb group (PcG) protein. SUZ12 is a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors.

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