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Anticorps Polyclonal de lapin anti-SVIP

SVIP Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 32511-1-PBS

Synonymes

Small VCP/p97-interacting protein

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using SVIP Polyclonal antibody (32511-1-AP)

    WB analysis using 32511-1-AP (same clone as 32511-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 32511-1-AP (SVIP antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 32511-1-PBS in a different storage buffer formulation.

Informations sur le produit

32511-1-PBS cible SVIP dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène SVIP Protéine recombinante Ag36618
Nom complet small VCP/p97-interacting protein
Masse moléculaire calculée8kDa
Poids moléculaire observé12 kDa
Numéro d’acquisition GenBankNM_001320340
Symbole du gène SVIP
Identification du gène (NCBI) 258010
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SVIP (Small VCP-interacting protein) is a 9-Kda adaptor endoplasmic reticulum protein that could bind directly to p97/VCP. SVIP is located on the ER membrane's cytosolic surface. It inhibits the ERAD pathway, which is known independently of ubiquitin, by interacting with p97/VCP, which has a central role in this pathway. Especially for the ERAD pathway, the SVIP protein has been identified as a negative regulator. SVIP was identified as a novel adapter protein for p97/VCP by observing its overexpression in cells, which causes extensive vacuolation and deformation of the ER and microtubules (PMID: 39473740).

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