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Anticorps Polyclonal de lapin anti-SYNCRIP

SYNCRIP Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30443-1-PBS

Synonymes

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using SYNCRIP Polyclonal antibody (30443-1-AP)

    WB analysis using 30443-1-AP (same clone as 30443-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 30443-1-AP (SYNCRIP antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30443-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A431 cells using SYNCRIP Polyclonal antibody (30443-1-AP)

    IF Staining of A431 using 30443-1-AP (same clone as 30443-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using SYNCRIP antibody (30443-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 30443-1-PBS in a different storage buffer formulation.

Informations sur le produit

30443-1-PBS cible SYNCRIP dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène SYNCRIP Protéine recombinante Ag31509
Nom complet synaptotagmin binding, cytoplasmic RNA interacting protein
Masse moléculaire calculée 623 aa, 70 kDa
Poids moléculaire observé62-74 kDa
Numéro d’acquisition GenBankBC032643
Symbole du gène SYNCRIP
Identification du gène (NCBI) 10492
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Synaptotagmin-binding, cytoplasmic RNA-interacting protein(SYNCRIP), also identified as hnRNP Q, involves in mRNA processing mechanisms. It's component of the CRD-mediated complex that promotes MYC mRNA stability. Also it is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. As previously reported, the 65 and 74 kDa proteins corresponded to two isoforms of SYNCRIP produced from alternatively spliced mRNAs (PMID: 15340051).

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