Anticorps Recombinant de lapin anti-Serotonin transporter

Serotonin transporter Recombinant Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242252B9

N° de cat : 84844-3-PBS

Synonymes

SLC6A4, 242252B9, 5 HTT, 5 HTTLPR, 5HTT

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Galerie de données de validation

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  WB analysis using 84844-3-RR (same clone as 84844-3-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84844-3-RR (Serotonin transporter antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84844-3-PBS in a different storage buffer formulation.

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  IHC staining of mouse lung using 84844-3-RR (same clone as 84844-3-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 84844-3-RR (Serotonin transporter antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Sodium Citrate buffer (pH 6.0). This data was developed using the same antibody clone with 84844-3-PBS in a different storage buffer formulation.

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Informations sur le produit

84844-3-PBS cible Serotonin transporter dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
• Masse moléculaire calculée: 70 kDa
• Poids moléculaire observé: 70 kDa
• Numéro d’acquisition GenBank: NM_001045
• Symbole du gène: Serotonin transporter
• Identification du gène (NCBI): 6532
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Serotonin transporter (SERT; SLC6A4) belongs to the sodium- and chloride-dependent monoamine transporter family. SERT is a membrane transporter that terminates the neurotransmission of serotonin, a monoaminergic neurotransmitter, through its reuptake. The SERT uptake mechanism acquires energy for active transport via ATP hydrolysis or movement against electrochemical gradients. As an oligomeric N-glycan, SERT contains disulfide bonds between cysteine residues on the second extracellular domain. Post-translational modifications regulate the uptake kinetics and membrane trafficking of SERT, partly by regulating the proper folding and assembly of SERT in a host-dependent manner (PMID: 30394319).

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