Anticorps Recombinant de lapin anti-Serpin A4/Kallistatin

Serpin A4/Kallistatin Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

251716C12

N° de cat : 86758-3-PBS

Synonymes

Kallistatin, Serpin A4, KAL, Kallikrein inhibitor, KLST

---

Galerie de données de validation

• 

  WB analysis of human plasma using 86758-3-RR (same clone as 86758-3-PBS)

  Human plasma was subjected to SDS PAGE followed by western blot with 86758-3-RR (Serpin A4/Kallistatin antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86758-3-PBS in a different storage buffer formulation.

---

Informations sur le produit

86758-3-PBS cible Serpin A4/Kallistatin dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Serpin A4/Kallistatin Protéine recombinante Eg4707
• Nom complet: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
• Masse moléculaire calculée: 49 kDa
• Poids moléculaire observé: 49 kDa
• Numéro d’acquisition GenBank: NM_001289033.1
• Symbole du gène: Kallistatin
• Identification du gène (NCBI): 5267
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Serpin A4 is also named Kallistatin and Peptidase inhibitor 4 (PI-4). Kallistatin was first identified in human plasma as a tissue kallikrein-binding protein and a serine proteinase inhibitor. Kallistatin via its two structural elements regulates differential signaling cascades, and thus a wide spectrum of biological functions (PMID: 28427524). Kallistatin via the active site promotes neovascularization by stimulating VEGF levels in endothelial progenitor cells. Second, kallistatin inhibits or induces apoptosis depending on cell types. Kallistatin via its heparin-binding site inhibits angiogenesis by blocking vascular endothelial growth factor (VEGF)-induced growth, migration and adhesion of endothelial cells. Kallistatin can act as an antioxidant or pro-oxidant (PMID: 28742513).

{{ptg:RelatedPrimaryAntibodies}}