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Anticorps Recombinant de lapin anti-Serpin B3/4

Serpin B3/4 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250057B3

N° de cat : 85807-2-PBS

Synonymes

SERPINB3, SERPINB3/4, Protein T4 A, Protein T4-A, SCCA-1

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using Serpin B3/4 Recombinant antibody (85807-2-RR)

    WB analysis using 85807-2-RR (same clone as 85807-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85807-2-RR (SERPINB3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85807-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85807-2-RR

    Affinity and Kinetic Characterization of 85807-2-RR

    Biolayer interferometry (BLl) kinetic assays of 85807-2-RR against Human Serpin B3/4 were performed. The affinity constant is 0.95 nM.

Informations sur le produit

85807-2-PBS cible Serpin B3/4 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Serpin B3/4 Protéine recombinante Ag24846
Nom complet serpin peptidase inhibitor, clade B (ovalbumin), member 3
Masse moléculaire calculée 390 aa, 45 kDa
Poids moléculaire observé45 kDa
Numéro d’acquisition GenBankBC005224
Symbole du gène SERPINB3
Identification du gène (NCBI) 6317
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4) are members of the ovalbumin family of serine proteinase inhibitors. SCCA1 and SCCA2 are highly homologous proteins, 91% identical at the amino acid level, and probably evolving from a common ancestor gene. The neutral form of SCCA (SCCA1, or SERPINB3) is detected in the cytoplasm of normal and some malignant squamous cells, whereas the acidic form (SCCA2, or SERPINB4) is expressed primarily in malignant cells and is the major form found in the plasma of cancer patients. SCCA2 (SERPINB4), along with SCCA1(SERPINB3), can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. This antibody can recognize both SerpinB3 and SerpinB4.

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