Anticorps Polyclonal de lapin anti-SerpinB3/SerpinB4

SerpinB3/SerpinB4 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11428-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 11428-1-AP (same clone as 11428-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11428-1-AP (SERPINB4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11428-1-PBS in a different storage buffer formulation.

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  WB analysis of COLO 320 using 11428-1-AP (same clone as 11428-1-PBS)

  COLO 320 cells were subjected to SDS PAGE followed by western blot with 11428-1-AP (SERPINB4 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11428-1-PBS in a different storage buffer formulation.

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Informations sur le produit

11428-1-PBS cible SerpinB3/SerpinB4 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: SerpinB3/SerpinB4 Protéine recombinante Ag1964
• Nom complet: serpin peptidase inhibitor, clade B (ovalbumin), member 4
• Masse moléculaire calculée: 390 aa, 45 kDa
• Poids moléculaire observé: 42-45 kDa
• Numéro d’acquisition GenBank: BC017401
• Symbole du gène: SERPINB4
• Identification du gène (NCBI): 6318
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Squamous cell carcinoma antigens 1 and 2 (SCCA1 and 2, SERPIN B3 and B4) are members of the ovalbumin family of serine proteinase inhibitors. SCCA1 and SCCA2 are highly homologous proteins, 91% identical at the amino acid level, and probably evolving from a common ancestor gene. The neutral form of SCCA (SCCA1, or SERPINB3) is detected in the cytoplasm of normal and some malignant squamous cells, whereas the acidic form (SCCA2, or SERPINB4) is expressed primarily in malignant cells and is the major form found in the plasma of cancer patients. SCCA2 (SERPINB4), along with SCCA1(SERPINB3), can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. This antibody can recognize both SerpinB3 and SerpinB4.

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