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Anticorps Polyclonal de lapin anti-Siglec-12

Siglec-12 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, porc, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 13964-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of various lysates using Siglec-12 Polyclonal antibody (13964-1-AP)

    WB analysis using 13964-1-AP (same clone as 13964-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13964-1-AP (SIGLEC12 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13964-1-PBS in a different storage buffer formulation.

Informations sur le produit

13964-1-PBS cible Siglec-12 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, porc, rat, souris

Réactivité Humain, porc, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène Siglec-12 Protéine recombinante Ag4939
Nom complet sialic acid binding Ig-like lectin 12
Masse moléculaire calculée 595 aa, 65 kDa
Poids moléculaire observé70 kDa
Numéro d’acquisition GenBankBC035809
Symbole du gène SIGLEC12
Identification du gène (NCBI) 89858
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily that contain sialoside-binding N-terminal domains (PMID: 22749793). Sialic acid binding Ig-like lectin 12 (Siglec-12, also known as S2V, SLG, SIGLECL1, and Siglec-XII) is a member of the SIGLEC3-like subfamily of SIGLECs, which is highly expressed in the spleen, such as CD8+ cells, macrophages, neutrophils, and dendritic cells. It mediates sialic-acid-dependent binding to cells and could be an identification of therapeutic targets and prognostic biomarkers of sarcomas (PMID: 38182638).

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