Anticorps Recombinant de lapin anti-Siglec-7/CD328
Siglec-7/CD328 Recombinant Antibody for
Hôte / Isotype
Lapin / IgG
Réactivité testée
Humain
Applications
Conjugaison
CoraLite®488 Fluorescent Dye
CloneNo.
241525H1
N° de cat : CL488-98183
Synonymes
Galerie de données de validation
Informations sur le produit
CL488-98183 cible Siglec-7/CD328 dans les applications de et montre une réactivité avec des échantillons Humain
| Réactivité | Humain |
| Hôte / Isotype | Lapin / IgG |
| Clonalité | Recombinant |
| Type | Anticorps |
| Immunogène | Siglec-7/CD328 Protéine recombinante Eg1545 |
| Nom complet | sialic acid binding Ig-like lectin 7 |
| Masse moléculaire calculée | 51 kDa |
| Numéro d’acquisition GenBank | NM_014385.4 |
| Symbole du gène | Siglec-7 |
| Identification du gène (NCBI) | 27036 |
| Conjugaison | CoraLite®488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 491 nm / 516 nm |
| Forme | Liquide |
| Méthode de purification | Protein A purfication |
| Tampon de stockage | PBS with 0.09% sodium azide and 0.5% BSA |
| Conditions de stockage | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Informations générales
Sialic acid binding Ig-like lectin 7 (Siglec-7), also known as CD328 or p75/AIRM-1, is a member of the Siglec family of glycan-recognition proteins. Siglec-7 is a type-I transmembrane protein consisting of three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two tyrosine residues embodied in immunoreceptor tyrosine-based inhibition motif-like motifs (PMID: 32322597; 10567377). It is mainly expressed on immune cells, with low levels on granulocytes, intermediate levels on monocytes, and relatively high levels on a major subset of natural killer cells and a minor subset of CD8+ T cells (PMID: 10567377). Siglec-7 is an inhibitory receptor that negatively regulates the function of NK cells and modulates the immune response through the interaction of sialic acid-containing ligands (PMID: 27312286).
