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Anticorps Recombinant de lapin anti-Spartin/SPG20

Spartin/SPG20 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250440A11

N° de cat : 85938-2-PBS

Synonymes

SPG20, KIAA0610, SPART, Spartin, SPG 20

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using Spartin/SPG20 Recombinant antibody (85938-2-RR)

    WB analysis using 85938-2-RR (same clone as 85938-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85938-2-RR (Spartin/SPG20 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85938-2-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 85938-2-RR

    Affinity and Kinetic Characterization of 85938-2-RR

    Biolayer interferometry (BLl) kinetic assays of 85938-2-RR against Human Spartin/SPG20 were performed. The affinity constant is 1.66 nM.

Informations sur le produit

85938-2-PBS cible Spartin/SPG20 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène Spartin/SPG20 Protéine recombinante Ag4815
Nom complet spastic paraplegia 20 (Troyer syndrome)
Masse moléculaire calculée 72 kDa
Poids moléculaire observé 75-84 kDa
Numéro d’acquisition GenBankBC047083
Symbole du gène Spartin
Identification du gène (NCBI) 23111
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par protéine A
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

SPG20 (spastic paraplegia 20) gene encodes a multifunctional Spartin protein. SPG20 protein is highly expressed in adipose tissue and may be implicated in endosomal trafficking and microtubule dynamics. SPG20 is mutated in Troyer syndrome, a hereditary spastic paraplegia defined by degeneration of upper motor neurons, recent study showed that regulation of SPG20 on mitochondrial calcium homeostasis may contribute to the pathophysiology of Troyer syndrome. Hypermethylation of SPG20 promoter, found in colorectal cancer patients, may play a role in cytokinesis arrest in colorectal tumorigenesis.

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