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Anticorps Polyclonal de lapin anti-TANC2

TANC2 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31541-1-PBS

Synonymes

ROLSA, rols, KIAA1636, KIAA1148

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using TANC2 Polyclonal antibody (31541-1-AP)

    WB analysis using 31541-1-AP (same clone as 31541-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31541-1-AP (TANC2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31541-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using TANC2 Polyclonal antibody (31541-1-AP)

    IF Staining of HeLa using 31541-1-AP (same clone as 31541-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HeLa cells using TANC2 antibody (31541-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 31541-1-PBS in a different storage buffer formulation.

Informations sur le produit

31541-1-PBS cible TANC2 dans les applications de WB, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène TANC2 Protéine recombinante Ag35427
Nom complet tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Masse moléculaire calculée219kDa
Poids moléculaire observé220 kDa
Numéro d’acquisition GenBankNM_001394998
Symbole du gène TANC2
Identification du gène (NCBI) 26115
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Tetratricopeptide repeat, ankyrin repeat, and coiled-coil containing 2 (TANC2), also known as KIAA1148 and KIAA1636, belongs to the TANC family. TANC2 is a large 220 kDa protein consisting of 1990 amino acid residues. Named after its domain architecture, it comprises tetratricopeptide (TPR) and ankyrin repeats (ANK), a coiled-coil domain, and a C-terminal PDZ-interacting motif. TANC2 is widely expressed in the developing human (in excitatory neurons and radial glial cells) and rodent brain as well as in the adult brain as a scaffold in the postsynaptic density (PSD) of excitatory neurons. As such, it facilitates cell signaling downstream of cell surface glutamate receptors through multi-protein complex formation with other PSD proteins (e.g. PSD95, SHANK1), influencing dendritic spine formation and synaptic strength (PMID: 33976205, 34964047).

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