Anticorps Polyclonal de lapin anti-TBC1D8

TBC1D8 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33583-1-PBS

Synonymes

AD 3, TBC1 domain family member 8, Vascular Rab-GAP/TBC-containing protein, VRP

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Galerie de données de validation

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  WB analysis using 33583-1-AP (same clone as 33583-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 33583-1-AP (TBC1D8 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33583-1-PBS in a different storage buffer formulation.

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  IHC staining of human cervical cancer using 33583-1-AP (same clone as 33583-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue slide using 33583-1-AP (TBC1D8 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 33583-1-PBS in a different storage buffer formulation.

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Informations sur le produit

33583-1-PBS cible TBC1D8 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TBC1D8 Protéine recombinante Ag35398
• Nom complet: TBC1 domain family, member 8 (with GRAM domain)
• Masse moléculaire calculée: 130kDa
• Poids moléculaire observé: 130 kDa
• Numéro d’acquisition GenBank: NM_001102426
• Symbole du gène: TBC1D8
• Identification du gène (NCBI): 11138
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The TBC1D8 protein is a member of the TBC domain family and functions as a GTPase-activating protein (GAP) that negatively regulates the activity of small G proteins of the Rab family, participating in the fine-tuning of intracellular vesicle transport and signal transduction. This protein has garnered significant attention in reproductive and cancer research. Studies have shown that TBC1D8 is a key determinant of oocyte maturation and female fertility, with defects in its expression leading to embryonic development arrest. Moreover, TBC1D8 is abnormally overexpressed in various cancers (such as breast and lung cancer), where it acts as an oncogene by modulating signaling pathways related to cell proliferation, invasion, and metastasis (e.g., the EGFR/Ras pathway). Thus, it serves as a potential biomarker for disease diagnosis and a therapeutic target.

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