Anticorps Recombinant de lapin anti-TCF1/TCF7

TCF1/TCF7 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241154D2

N° de cat : 84089-4-PBS

Synonymes

TCF7, 241154D2, T cell factor 1, TCF 1, TCF 7

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Galerie de données de validation

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  WB analysis using 84089-4-RR (same clone as 84089-4-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 84089-4-RR (TCF7 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84089-4-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 84089-4-RR

  Biolayer interferometry (BLl) kinetic assays of 84089-4-RR against Human TCF1/TCF7 were performed. The affinity constant is below 1 pM.

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Informations sur le produit

84089-4-PBS cible TCF1/TCF7 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: TCF1/TCF7 Protéine recombinante Ag5792
• Nom complet: transcription factor 7 (T-cell specific, HMG-box)
• Masse moléculaire calculée: 42 kDa
• Poids moléculaire observé: 58 kDa
• Numéro d’acquisition GenBank: BC048769
• Symbole du gène: TCF1/TCF7
• Identification du gène (NCBI): 6932
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TCF7, also known as TCF1, belongs to the TCF/LEF family. TCF7 is part of the Wnt signaling pathway and plays an important role in the differentiation and self-renewal of memory T cells. It has been found that TCF7 is necessary to revive T cells in response to PD-1 blockade against viral infection or cancer. TCF7 is mainly expressed in T-cells and is also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. TCF7 has 16 isoforms with the molecular mass of 28-54 kDa (PMID: 34044317).

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