Anticorps Monoclonal anti-TCF7L1/TCF7L2

TCF7L1/TCF7L2 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

2B2D12

N° de cat : 67652-1-PBS

Synonymes

HMG box transcription factor 3, HMG box transcription factor 4, TCF 3, TCF 4, TCF3, TCF4, TCF7L1, TCF7L2, Transcription factor 7 like 1

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Galerie de données de validation

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  WB analysis using 67652-1-Ig (same clone as 67652-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67652-1-Ig (TCF7L1/TCF7L2 antibody) at dilution of 1:50000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67652-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67652-1-PBS cible TCF7L1/TCF7L2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: TCF7L1/TCF7L2 Protéine recombinante Ag28954
• Nom complet: transcription factor 7-like 1 (T-cell specific, HMG-box)
• Masse moléculaire calculée: 63 kDa
• Poids moléculaire observé: 70 kDa
• Numéro d’acquisition GenBank: BC058894
• Symbole du gène: TCF7L1
• Identification du gène (NCBI): 83439
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. This antibody raised against 1-200aa of human TCF7L1 can also react with TCF7L2.

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