Anticorps Polyclonal de lapin anti-TCTN3

TCTN3 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 16085-1-PBS

Synonymes

TECT3, TCTN 3, PSEC0041, OFD4, JBTS18

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Galerie de données de validation

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  WB analysis using 16085-1-AP (same clone as 16085-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16085-1-AP (TCTN3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IP experiment of Hela cells using 16085-1-AP (same clone as 16085-1-PBS)

  IP result of anti-TCTN3 (16085-1-AP for IP and Detection). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung using 16085-1-AP (same clone as 16085-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung using 16085-1-AP (TCTN3 antibody) at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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  IHC staining of human lung using 16085-1-AP (same clone as 16085-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human lung using 16085-1-AP (TCTN3 antibody) at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 16085-1-PBS in a different storage buffer formulation.

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Informations sur le produit

16085-1-PBS cible TCTN3 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: TCTN3 Protéine recombinante Ag9084
• Nom complet: tectonic family member 3
• Masse moléculaire calculée: 607 aa, 66 kDa
• Poids moléculaire observé: 66 kDa
• Numéro d’acquisition GenBank: BC009494
• Symbole du gène: TCTN3
• Identification du gène (NCBI): 26123
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

TCTN3 (tectonic-3 or TECT3) is a type I membrane protein that belongs to the tectonic family, which consists of TCTN1, TCTN2 and TCTN3. Studies in mice suggest that tectonic may be involved in Hedgehog (Hh) signaling, and essential for ciliogenesis. Tectonic is component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. TCTN3 is necessary for transduction of the sonic hedgehog (SHH) signaling pathway. Orofaciodigital syndromes (OFDSs) consist of a group of heterogeneous disorders characterized by abnormalities in the oral cavity, face, and digits and associated phenotypic abnormalities. Recently, TCTN3 mutations are found as the cause of an extreme form of OFD associated with bone dysplasia, tibial defect, cystic kidneys, and brain anomalies.

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